Adaptation of Scalable Technologies to Illuminate the Druggable Genome (U01)

archived

The overarching goals of this Funding Opportunity Announcement (FOA) and the companion announcement (RFA-RM-13-011) are to foster the development of technologies and information management to facilitate the unveiling of the functions of the poorly characterized and/or un-annotated members in four protein classes of the Druggable Genome. This FOA calls for adaptation of an ensemble of scalable technology platforms to characterize functions of proteins as a large group at molecular and cellular levels in medium- to high-throughput fashion, rather than repeating the one at a time approach that might otherwise be undertaken. The objective is to establish transformative scalable technology platforms and streamlined experimental workflows incorporated with multiple robust assay and physiological perturbation protocols for large-scale functional studies of poorly characterized and/or un-annotated proteins encoded by the Druggable Genome.

High