Advances in Polycystic Kidney Disease (R01)

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The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) through its Division of Kidney, Urologic and Hematologic Diseases (DKUHD) invites experienced and new investigators to submit research grant applications to pursue basic and applied investigations in order to better understand the etiology and pathogenesis of Polycystic Kidney Disease (PKD), in both its autosomal dominant and autosomal recessive forms. Such applications may examine the genetic determinants, and cellular and molecular mechanisms, which disrupt normal kidney function; mechanisms of cyst formation and growth; development of experimental model systems; development of markers of disease progression; and the identification of innovative therapeutic interventions and gene targeted strategies to prevent progressive renal insufficiency due to this disorder. The intent of this funding opportunity is to intensify investigator-initiated research, to attract new investigators to the field, and to increase interdisciplinary research. The ultimate aim is to facilitate PKD-related research studies, which will provide the basis for new therapeutic approaches.

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