Aging Musculoskeletal and Skin Extracellular Matrix (R21)

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The objective of this funding opportunity announcement (FOA) is to solicit grant applications for basic research projects to investigate how changes in the extracellular matrix with age affect the function of the tissues of the musculoskeletal system and skin. Projects are encouraged that determine how cellular aging processes lead to altered matrix production and maintenance, and how aging-related altered matrix composition and organization affect the function of these tissues. This funding opportunity utilizes the NIH R21 Exploratory/Developmental Research Grant award mechanism and runs in parallel with a program announcement of identical scientific scope that utilizes the traditional research project grant (R01) mechanism (PA-03-167). The number of awards made under this solicitation will depend on the overall scientific merit of the applications and the availability of funds. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

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