Alcohol-Induced Metabolic and Hepatic Injury (AIMHI) (R01)

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Purpose. The goal of this Funding Opportunity Announcement (FOA), issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), is to stimulate innovative research that will determine the key cellular and molecular events responsible for the progression of alcohol-induced fatty liver to fibrosis and cirrhosis in patients with alcoholic liver disease (ALD) alone or in combination with obesity, diabetes or Hepatitis C infection. We anticipate that the results of such research will identify the mechanisms responsible for the increased susceptibility to the progression of ALD to end-stage liver disease and help identify promising molecular targets for early detection of the most at-risk population. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism. Funds Available and Anticipated Number of Awards. The NIAAA intends to commit a total of approximately $1,500,000 to this FOA to award up to 6 applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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