Alliance of Glycobiologists for Detection of Cancer (U01)

archived

The purpose of this Funding Opportunity Announcement (FOA) is to continue support for the program referred to as the Alliance of Glycobiologists for Detection of Cancer (http://glycomics.cancer.gov). Through this FOA, the NCI solicits new and competing renewal applications for research projects to elucidate how changes in cellular carbohydrates may promote cancer initiation and progression and use this information to identify glycan-based abnormalities that have the potential to serve as biomarkers for early cancer detection or risk assessment. These changes may be studied at the level of glycoproteins, glycolipids, glycosaminoglycans, and/or their binding proteins. The proposed projects must also address the ability of these biomarker candidates to accurately distinguish individuals with cancer from those without. It is expected that the most promising biomarker candidates will ultimately be tested in clinical validation studies, although such validation studies are not required for the proposed projects. In addition to planning for the individual research projects, the applicants responding to this FOA must plan for the participation in trans-Alliance activities, including collaborative projects with other awardees.

High