Alzheimer's Disease Pilot Clinical Trials (R01)

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In 1999, at the direction of Congress, the National Institute on Aging (NIA), in conjunction with the National Institute of Neurological Disorders and Stroke (NINDS), the National Institute of Mental Health (NIMH), and the National Institute of Nursing Research (NINR) embarked on the Alzheimer's Disease (AD) Prevention Initiative, which encompasses a number of interrelated efforts including basic, epidemiological, behavioral, and clinical research. An important part of the AD Prevention Initiative is to quicken the pace for translating basic science findings into clinical trials to evaluate treatment and prevention strategies. This funding opportunity announcement (FOA) focuses on AD pilot clinical trials while other FOAs are targeted to AD drug discovery and development. In this FOA the National Institute on Aging (NIA) invites qualified investigators to submit research grant applications for pilot clinical trials using pharmacologic and/or behavioral interventions directed toward the prevention and treatment of the cognitive and behavioral symptoms of mild cognitive impairment (MCI), Alzheimer's disease (AD), and age-related cognitive decline.

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