Atopic Dermatitis Research Network (ADRN) (U19)

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This Funding Opportunity Announcement (FOA) solicits applications from institutions to administer a multi-project, multi-institution program to conduct clinical research and provide the leadership and administrative responsibilities for the Atopic Dermatitis Research Network (ADRN). The ADRN conducts clinical research studies to better understand host defense mechanisms in the skin, by comparing responses to infections and vaccines, and underlying mechanisms, in healthy, non-atopic individuals vs. those with atopic dermatitis (AD). Such effects include skin barrier and adaptive and innate immune system responses to viral and bacterial infections, and genetic and epigenetic studies. The scope of research supported under this FOA will include the role of the microbiome in regulating host defense, and the development of clinical interventions to enhance host defense. The FOA will also support the conduct of longitudinal studies aiming at the identification of AD phenotypes pertaining to clinical presentation, skin and peripheral blood immunologic responses and patterns of cutaneous host defense.

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