Audacious Goals Initiative High Priority Research Area: Intersection of Aging and Biological Mechanisms of Eye Disease (R01)

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The purpose of this Funding Opportunity Announcement (FOA) for the National Eye Institute (NEI) is to encourage submission of new, innovative projects directed to exploring this area through: 1) understanding how the biology of aging contributes to disease; 2) evaluating how the failure of homeostatic processes causes or allows the transition from aging to early disease; 3) defining the biological staging of disease to understand pathophysiology, identify biomarkers, and explore therapy; and 4) distinguishing normal ocular changes associated with aging from pathophysiologic changes. Advanced age is a risk factor for many of the leading causes of vision loss, including age-related macular degeneration, cataract, glaucoma, diabetic retinopathy, dry eye syndrome, and presbyopia. Better knowledge of the biological mechanisms of disease will lead to new strategies to prevent or delay progress of these age-related blinding conditions. An application may propose design-directed, developmental, discovery-driven, or hypothesis-driven research. It is appropriate to propose small, multidisciplinary teams applying an integrative approach to solve these problems.

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