Awards to Support Research on the Biology of Aging in Invertebrates (R01)

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Purpose: This Funding Opportunity Announcement (FOA) issued by the National Institute on Aging (NIA), National Institutes of Health, invites applications (R01) that propose the identification and development of new invertebrate models for pursuing biology of aging research. Applications should focus on the identification, development and characterization of new invertebrate models that have short lifespans. Invertebrate models with tractable genetics and genome sequence available or in progress, negligible or induced senescence, and tissue regeneration in adults are of particular interest to NIA. Examples of invertebrate models of interest include, but are not limited to planaria, hydra, rotifers, and tunicates. These invertebrate models are currently not well developed for aging research. Within the scope of this FOA, invertebrate models other than those mentioned above currently used by the biomedical research community, but not yet fully developed or realized for aging research, will be considered responsive to this FOA. In particular, applications that focus on the characterization of these novel models for aging research utilizing molecular, genetic, cellular or physiological tools and approaches to identify genes involved in longevity, senescence and cellular pathways in tissue homeostasis during aging are encouraged. Applications that propose work on invertebrate models such as Caenorhabditis elegans, Drosophila melanogaster or yeast, Saccharomyces cerevisiae, will be considered non-responsive to this FOA. Mechanism of Support. This FOA will utilize the R01 grant mechanism. Funds available and Anticipated Number of Awards. The total amount of NIA FY2010 funds is $2.0 million. The anticipated number of NIA awards is 5 to 6. Each award may have up to a five year term.

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