B Cell Immunology Partnership Program For HIV-1 Vaccine Discovery (U19)

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Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, (NIH) solicits grant applications from institutions/organizations that propose multidisciplinary research to define the basic immune mechanisms by which a broadly cross-reactive neutralizing antibody response can be elicited in uninfected individuals to protect against infection by a broad range of HIV-1 strains. Specifically, this FOA will support innovative studies to identify new HIV-1 envelope immunogens and immunization strategies for induction of broadly cross-reactive neutralizing antibody, and basic B cell immunology research designed to increase fundamental knowledge of the immunological mechanisms involved in the induction and regulation of immune responses leading to an HIV-1 broadly cross-reactive neutralizing antibody response. Preliminary data are required, and expertise in basic immunology and the HIV-1 virus should be evident. This multi-project cooperative agreement grant program will support a partnership to communicate ideas and progress among recipients of U19 awards as well as recipients of previous U01 awards issued under B Cell Immunology for Protective HIV-1 Vaccines (RFAAI-07-014). Clinical trials will not be supported by this FOA.

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