Basic Research on HIV Persistence (R01)

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Purpose. The aim of this Funding Opportunity Announcement (FOA) issued by the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), is to increase our understanding of persistent HIV-1 infection in patients under highly active anti-retroviral therapy (HAART). Support would be through soliciting Research Project Grant (R01) applications for hypothesis-driven basic research in HIV/AIDS that is focused on directly achieving this aim. The emphasis of this initiative is on the development of new ideas and approaches in HIV-1 persistence including model and assay development that may directly inform future studies on the design of therapeutic strategies to achieve long term remission without treatment or a complete eradication of residual virus and complete cure for HIV infection and AIDS. It is anticipated that this is the first in a series of FOAs to understand the basic mechanisms of HIV persistence and then to use this information to develop ways to control and eliminate the virus-carrying cells. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the, numbers, quality, duration, and costs of the applications received.

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