Behavioral Epigenomics of Aging in Twin Studies (U24)

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Twin research supported by the National Institute on Aging has transformed our understanding of behavior over the lifespan and allowed us to study the interplay of genetic and environmental factors that affect how we age (e.g. lifestyle factors, socio-economic status, social engagement), age-related changes in behavior (e.g. cognition, personality) and behavioral concomitants of healthy aging (e.g. well-being) using primarily a quantitative genetic approach. The purpose of this FOA is to accelerate progress in behavioral genomics and aging via the establishment of a twin-epigenomic network that will facilitate collaboration between existing twin studies of aging, including work on the harmonization of phenotypes and (epi)genotype collection procedures as well as the development of statistical methods for the analysis and meta-analysis of data sets including genomic, epigenomic, gene expression, and behavioral phenotypic data. Larger scale support for the collection of samples suitable for epigenomic analysis in specific studies may be supported by other opportunities.

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