Bile Acid Nanosystems as Molecule Carriers in Pharmaceutical Applications

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The goal of this project is to research the usefulness of the synthesized bile acid (BA) oxo derivatives as excipients in pharmaceutical preparations of some drugs. Pharmaceutical preparations whose active components are molecular packed with BA are expected to show the higher degree of active substance efficiency. Direct use of BAs in the elimination of cholesterol will be analyzed as well. The project starts from basic sciences such as chemistry and proceeds to applied biomedical sciences. Direct project phases are the synthesis of BA oxo derivatives and their characterization, necessary for rational pharmaceutical and biochemical research. Since the early seventies the chemistry and pharmacology of BAs is intensively investigated at the Univ. of Novi Sad. Besides the extensive and precious experience of the scientist from the Univ. of Novi Sad with the behaviour of BAs, the Univ. of Szeged possesses modern and powerful equipment for the research of chemical interactions. Well-developed chemical informatics (computational cluster) at the University of Szeged allows for modelling the structure of BA aggregates, in order to be able to select drug molecules with which BA will interact. Using new computational techniques (University of Szeged) allows reducing the use of chemicals in direct experiments as well as the associated economic burden and the environmental pollution. Using cheaper BAs, drug doses can be reduced (for example doses of morphine), for this reason understanding the chemistry of such nanoclusters is crucial. Beside that, the use of BAs would affect breeding of animals for slaughter and affect meat industry, where bile remains as a byproduct and BAs can be isolated from it. Indirectly, one target group is that of patients with high cholesterol level. If a several months long investigation on animals shows that BA oxo derivatives are not toxic, then clinical investigations can be conducted in the long term.

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