Bioenergetics, Fatigability, and Activity Limitations in Aging (R01)

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Purpose. This FOA issued by the National Institute on Aging (NIA), the National Heart, Lung, and Blood Institute (NHLBI), the National Institute of Nursing Research (NINR), the Office of Research on Womens Health (ORWH), and the Office of Dietary Supplements (ODS). encourages Research Project Grant (R01) applications proposing to study bioenergetic factors underlying increased fatigability and activity limitations in aging. Increased fatigability is a significant cause of restricted physical and cognitive activity in older adults. Alterations in bioenergeticsthe production and utilization of energy, and the regulation of these processesmay contribute significantly to increased fatigability. This FOA encourages applications that propose to 1) elucidate specific alterations in bioenergetics related to increased fatigability and activity limitations; 2) develop and evaluate improved measures of fatigability related to bioenergetics; 3) evaluate interventions for increased fatigability and activity limitations that target alterations in bioenergetics and lead to improved quality of life. Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) grant mechanism and runs in parallel with FOAs of identical scientific scope, PA-09-192, that encourages applications under the R03 Small Research Grant mechanism, and PA-09-191, that encourages applications under the R21 Exploratory/Developmental grant mechanism.

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