Bioenergetics, Fatigability, and Activity Limitations in Aging (R21)

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Purpose. This FOA issued by the National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Nursing Research, Office of Research on Womens Health, and the Office of Dietary Supplements encourages R21 applications proposing to study bioenergetic factors underlying increased fatigability and activity limitations in aging. Increased fatigability is a significant cause of restricted physical and cognitive activity in older adults. Alterations in bioenergeticsthe production and utilization of energy, and the regulation of these processesmay contribute significantly to increased fatigability. This FOA encourages applications that propose to 1) elucidate specific alterations in bioenergetics related to increased fatigability and activity limitations; 2) develop and evaluate improved measures of fatigability related to bioenergetics; 3) evaluate interventions for increased fatigability and activity limitations that target alterations in bioenergetics and lead to improved quality of life. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism and runs in parallel with a FOA of identical scientific scope, PA-09-190, that encourages applications under the Research Project Grant (R01) mechanism, and PA-09-192, that encourages applications under the Small Research Grant (R03) mechanism. Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism, numbers, quality, duration, and costs of the applications received.

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