Brain Somatic Mosaicism and its Role in Psychiatric Disorders (U01)

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This funding opportunity announcement (FOA) invites Cooperative Agreement (U01) applications from multi-disciplinary and synergistic teams of investigators proposing to identify and characterize the full spectrum of somatic variation in human brain samples and to assess the relationship of such variation with the pathophysiology of neuropsychiatric disorders.This FOA seeks to support applications exploring the extent of somatic variations across different brain regions in one or more psychiatric disorders using state-of-the-art genomic, computational and single-cell approaches.Awards made under this FOA will be governed by a Brain Somatic Mosaicism (BSM) Network Steering Committee to accelerate scientific progress through the coordination of research strategies, analytical methods and data.The ultimate goal of this FOA is to address gaps in our understanding of the role of somatic genomic perturbations in the etiology of neuropsychiatric disorders.

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