Building Complex 3-Dimensional in Vitro Human Musculoskeletal and Skin Tissue Models (R43)

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This Funding Opportunity Announcement (FOA) solicits Phase I R43 SBIR grant applications from small businesses to develop novel complex 3-dimensional (3-D) in vitro human musculoskeletal and skin tissue models that fit into the NIAMS mission (http://www.niams.nih.gov/About_Us/Mission_and_Purpose/mission.asp). These engineered 3-D human tissue or organ models would provide alternatives to animal models of diseases and animal testing, and enable the study of human tissue physiology and disease pathophysiology in vitro and ultimately lead to better therapies that prevent or cure diseases. Applicants may propose to engineer novel in vitro models and/or develop novel technologies to meet some of the specific challenges in building these models. All applications need to use human cells in the context of in vitro 3-D culture, and must be immediately relevant to NIAMS mission areas. This FOA is not intended to support research using non-human cells or animals. Non-responsive applications will not be reviewed

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