Cancer Target Discovery and Development (CTDD) Network (U01)

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The purpose of this Funding Opportunity Announcement (FOA) and the Cancer Target Discovery and Development (CTDD) initiative is to promote innovative research on high throughput approaches to the discovery and characterization of new cancer targets and their modulators. Projects resulting from this FOA are expected to bridge the gap between the enormous volumes of data generated by the comprehensive molecular characterizations of many cancer subtypes and the ability to use these data for the development of human cancer therapeutics and associated response markers. Applicants must propose research projects focused on high-throughput identification and/or characterization of potential targets for cancer therapy, and/or the identification of small molecules that modulate validated cancer targets. Proposed projects are expected to combine in-depth mining of large-scale genomic data, systems biology analyses and/or experimental approaches to provide initial characterization of functional significance.

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