Catalytic META C-H ACYLation of arenes
Location: Italy
Source: EU Funding & Tenders Portal
Carbonylative C-H activations can lead to an unprecedented degree of molecular sophistication by combining the atom-economical insertion of CO with the green activation of unreactive C-H bonds. In striking contrast to ortho C-H acylation of arenes and heteroarenes (directing-group strategy) and para C-H ones (Friedel-Crafts chemistry), meta C-H acylations are almost completely unexplored. This pr
- Status
- Closed
- Location
- Italy
- Updated
- 22 Jul 2026
- Source
- EU Funding & Tenders Portal
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Status
Original status | ended |
Taiyo status | Closed |
Taiyo last update | 2026-07-22 |
Contact
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Description
Description | Carbonylative C-H activations can lead to an unprecedented degree of molecular sophistication by combining the atom-economical insertion of CO with the green activation of unreactive C-H bonds. In striking contrast to ortho C-H acylation of arenes and heteroarenes (directing-group strategy) and para C-H ones (Friedel-Crafts chemistry), meta C-H acylations are almost completely unexplored. This proposal aims at the development of the first example of meta C-H acylation via mild carbonylation of arenes. Pivoting on this breakthrough, it will be possible to accomplish synthetic methods 1) for the efficient synthesis of hardly accessible organic compounds, 2) for the activation and carbonylation of meta C(sp2)-H bonds, 3) by employing transient directing group and 4) demonstrating the application of these protocols under continuous flow conditions. |
Location
Country | Italy |
Source
Source | EU Funding & Tenders Portal |
URL |
More Details
Record type | Project |
Article published date | 2026-02-15 |
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