CDMRP Peer Reviewed Medical Research Program Investigator-Initiated Research Award

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The PRMRP Investigator-Initiated Research Award is intended to support studies that will make an important contribution toward research and/or patient care for a disease or condition related to at least one of the FY20 PRMRP Topic Areas. The rationale for a research idea may be derived from a laboratory discovery, population-based studies, a clinician’s first-hand knowledge of patients, or anecdotal data. Applications must include relevant data that support the rationale for the proposed study. These data may be unpublished or from the published literature. Impact: The Investigator-Initiated Research Award is designed to support research with the potential to yield highly impactful data that could lead to critical discoveries or major advancements. The application must clearly demonstrate the project’s potential short-term and long-term outcome(s)/product(s) (knowledge and/or materiel) and how they will impact a critical problem or question in the field of research and/or patient care in the FY20 PRMRP Topic Area(s) addressed. Research projects may focus on any phase of research from basic laboratory research through translational research, including preclinical studies in animal models and human subjects, as well as correlative studies associated with an existing clinical trial. Research involving human subjects and human anatomical substances is permitted; however, this award may not be used to conduct clinical trials. For more information on how to distinguish clinical research from clinical trials, see the Human Subject Resource Document at https://ebrap.org/eBRAP/public/Program.htm. Principal Investigators (PIs) seeking funding for a clinical trial should apply to the FY20 PRMRP Clinical Trial Award mechanism (Funding Opportunity Number: W81XWH-20-PRMRP-CTA). Partnering PI Option: As a method to facilitate progress in addressing critical problems or questions through collaborative efforts, the FY20 PRMRP is offering a Partnering PI Option for this award mechanism. The results of this partnering project should significantly advance the research beyond what would be possible through individual efforts. The Partnering PI Option is structured so that two investigators, each of whom will be designated as a PI, work synergistically on a single project. Each PI should bring complementary skills and perspectives to the research project. Developing the research plan should involve a reciprocal flow of ideas and information between the partners. The application should clearly demonstrate that both PIs have equal intellectual input into the design of the project and will devote similar and appropriate levels of effort to the conduct of the project. Each PI must demonstrate that they possess the research experience and resources to function as a PI and must also exhibit an appropriate level of authority and responsibility to direct the project supported by the awards. New and multi-institutional collaborative efforts are strongly encouraged. PIs should include plans for communication between investigators at different organizations, if applicable. Additionally, participating organizations must be willing to resolve potential intellectual and material property issues and to remove any barriers that might interfere with achieving high levels of cooperation to ensure successful completion of the proposed research project.

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