Centers for Mendelian Genomics (UM1)

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This FOA invites applications for the Centers for Mendelian Genomics Program (CMG Program). With this reissuance, NHGRI intends to achieve the following specific objectives. First, the Program will aim to discover as many genes that bear causal genetic variants ("causal genes") for human Mendelian diseases and non-disease Mendelian traits ("Mendelian conditions") as possible, using genome-wide sequencing and other complementary genomic approaches at the funded centers, and through collaborations with clinical and genetic researchers worldwide. Second, the Program will aim to enhance the chances of success in causal gene discoveries by improving sample solicitation strategies, discovery approaches, study designs, data analysis methods, and costs and efficiency of the discovery pipelines. Third, the Program will aim to enable others to discover more causal genes by disseminating the methods, tools, and other resources that will be developed under this FOA. Finally, the Program will facilitate common interests-based collaborations and avoid unproductive duplication of efforts on causal gene discoveries, through worldwide coordination. At a higher level, NHGRI intends that these activities will lead to insights on what methods, scale, and infrastructure will be necessary to discover all or most of the causal genes for human Mendelian conditions, and bring the field forward toward this goal.

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