ChemSyn (Aptuit) Pharmaceutical Manufacturing Plant

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ChemSyn Laboratories (now Aptuit), a leading producer of anti-cancer bulk pharmaceuticals and other high potency chemica 1998 Manufacturing plant for APIs, but also process development Harrisonville, USA $5m (new investment expected in 2007–2008 following takeover) 1999 ChemSyn Laboratories (EaglePitcher Technologies) Pfaudler supply the reactors. Buchii supply the chemreactor. Hamicon and Hastelloy supply some of the filter equipment 1 development work suite and 2 production suites 50l 10gal glass-lined Pfaudler reactor 30gal glass-lined Pfaudler reactor (2) 30gal stainless steel Pfaudler reactor 50gal glass-lined Pfaudler reactor (2) 100gal glass-lined Pfaudler reactor (3) 200gal glass-lined Pfaudler reactor 300gal glass-lined Pfaudler reactor (2) 300gal stainless steel Pfaudler reactor 50gal stainless steel kettle (2) 75gal glass-lined kettle 80gal miscellaneous receivers 50gal glass-lined receiver (2) 200gal glass-lined receiver 1,580gal storage tank Microware through 72l flasks 100l Buchii ChemReactor Dow Frost chiller (720,000 BTU/hr at-30_C) Supersaturated steam (150°C at 75 psi) Hot oil system for higher temperatures Stainless steel ribbon blender (3 cubic feet working capacity) Twin shell V-blender (1 cubic foot) Twin shell V-blender (16 qt.) Stainless steel rotary cone dryer (5 cubic feet working capacity) Stainless steel vacuum ovens (7.5 cubic feet) (3) Stainless steel Stokes Vacuum Tray Dryer Freeze-dryer (12l) Rotary evaporators (10 & 20l) (2) Stainless steel wiped film evaporator (0.25ft²) Fractionation column (15 HETP-3` x 1") Basket centrifuges-stainless steel (24") Sparkler filter-Hastelloy Sparkler filter-stainless steel Amicon DC-10L Dialysis-filtration system 150cfm NASH pump 30cfm NASH pump 40cfm high vacuum oil pump 300cfm high vacuum oil pump Miscellaneous: drum, transfer and metering pumps ChemSyn Laboratories (now Aptuit), a leading producer of anti-cancer bulk pharmaceuticals and other high potency chemicals, has announced the opening of a $5m expansion of its anti-cancer pharmaceutical manufacturing plant in Harrisonville, Montana in March 1999. The plant produces high-potency active pharmaceutical ingredients (APIs) for the eventual production of anti-cancer medicinal products by the company’s third-party customers. The majority of these chemicals are highly toxic and have to be produced under specialised cleanroom conditions, using barrier methods and special reactors. ChemSyn Laboratories is a department of Joplin, Montana-based EaglePicher Pharmaceutical Services. EaglePicher provides products and services to the aerospace, telecommunications, semiconductor and pharmaceutical industries and had annual revenue of about $900m. Leading suppliers to the plant were Pfaudler (reactors), Buchii (chemreactor), Hamicon and Hastelloy (filter equipment). COMPANY SOLD In October 2006 an offer was made for EaglePicher Pharmaceutical Services by Aptuit. The deal included the Harrisonville facility and also another plant in Lenexa, Kansas. This represented the entire pharmaceutical services division of EaglePicher. EaglePicher had to sell its pharmaceutical division as part of the restructuring of the company after going into Chapter 11 bankruptcy in August 2006. Aptuit is now in a position to offer various a number of new services to customers, including: process development, novel route development, pre-clinical drug substance supply, clinical/commercial drug substance supply, radio synthesis, small-scale commercial supply and technology transfer. UPGRADING The current facilities at Harrisonville are configured to provide from milligram to tonne scale production across the board. Aptuit will now make significant investments in the API operation in 2007–2008 to upgrade the Harrisonville facility and install new facilities. These include new lab-based process development and kilo lab capability, while the plant’s regulatory profile is set to improve. PRODUCTION AND DEVELOPMENT SUITES The plant features up-to-date barrier technology, including glove box isolation systems. The plant is divided into three suites: One is used for developmental work, and two are production suites. Each of the three suites has its own separate air-handling systems and access/egress points. One suite is a glassware laboratory used for preclinical and development work. The room is outfitted with a 100l Buchii Chemreacter, a walk-in hood for glassware up to 50l and a glove box for product isolation and packaging. The second and third suites are nearly identical production suites. One has a 30-and 100-gallon glass-lined reactor; the other contains a 100-gallon glass-lined reactor and an open bay for a second reactor. Both rooms employ CIP systems and contain custom-designed isolation glove boxes that filter, dry and package products, thus eliminating employee exposure and the risk of cross-contamination with other drugs. The plant has class 100,000 cleanrooms for use in development and production. PROCESS EQUIPMENT The process equipment available in the plant is made of reactors and process vessels. The reactors range from a 10-gallon glass-lined to 300-gallons glass lined (Pfaudler model). There are also a 30-gallon and 300-gallon stainless steel Pfandler reactors. Other process equipment is a 50-gallon and a 75-gallon glass lined kettle, 80-gallon miscellaneous receivers, a 50-gallon and a 200-gallon glass lined receivers, and a 1,580-gallon storage tank. The glassware is made of microware fitted, 72l flasks, together with a 100l Buchii chemreactor. COOLING AND HEATING The equipment for the cooling and heating function of the facility is made of a Dow frost chillier (720,000BTU/hr at -30°C), a supersaturated steam (150°C at 75psi), and a hot oil system for higher temperatures. BLENDERS The blenders employed are of different types. There is a stainless steel ribbon blender (3ft³ working capacity), a twin shell V-blender (1ft³), and a twin shell V-blender (16qt.). DRYERS There are four different types of dryer employed for the facility operations. A stainless steel rotary cone dryer (5ft³ working capacity), a stainless steel vacuum oven (7.5ft³), a stainless steel stokes vacuum tray dryer, and a freeze-dryer (12l). DISTILLATION EQUIPMENT The distillation equipment used are a rotary evaporators (10 and 20l), stainless steel wiped film evaporator (0.25ft²), and fractionation column (15 HETP-3′ x 1″). Filtration equipment is of four different types, used according to the operation needs. There are stainless steel basket centrifuges, a Hastelloy sparkler filter, a stainless steel sparkler filter and an Amicon DC-10L dialysis-filtration system. Get industry leading news, data and analysis delivered to your inbox Give your business an edge with our leading industry insights.

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