Computational Tool Development and Integrative Data Analysis for LINCS (U01)

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Purpose. This FOA encourages grant applications that would develop innovative computational tools and approaches for the integrative analysis of multiple types of data generated within the Library of Integrated Network-based Cellular Signatures (LINCS) program. Mechanism of Support. This FOA will utilize the U01 award mechanism. It is intended to complement RFA-RM-10-003, Large Scale Production of Perturbagen-Induced Cellular Signatures (U54), that establishes data production efforts to systematize approaches for identifying mechanism-based associations among the effects of disparate biological perturbations and a knowledge base to study functional relationships among the responding cellular components. Development for technologies for cellular signatures data generation to enhance LINCS will be supported through RFA-RM-10-004, which will be released in parallel to this FOA. Funds Available and Anticipated Number of Awards. We expect to fund up to four awards in FY 2011 from this solicitation. Two years of funding may be requested. The total amount available for these awards is approximately $1.4M in each of FY2011 and FY2012, contingent upon receiving scientifically meritorious proposals. For this funding opportunity, budgets up to $250,000 direct costs per year and time periods up to two years may be requested.

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