Computational Toxicology Research Centers: in vitro and in silico Models Of Developmental Toxicity Pathways

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The U.S. Environmental Protection Agency (EPA), as part of its Science to Achieve Results (STAR) program, is seeking applications proposing to develop in vitro and in silico (computational) models for developmental toxicity pathways. The STAR program is issuing this request for applications (RFA) for research that in conjunction with in vivo data, will seek to integrate in vitro biochemical and cellular response data with computational models and theoretical or applied mathematic techniques. The research conducted under this RFA will facilitate the development of a predictive capacity for estimating outcomes or risk associated with particular toxicity processes as a result of developmental exposure to environmental pollutants and toxicants. Predictive computational modeling of core processes that drive development, including patterning, morphogenesis, selective growth and cell differentiation, and the detailed understanding of biological pathways that regulate these processes have the potential to address environmental and human health factors with broad scientific or economic impacts.

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