Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01)

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Purpose. This Funding Opportunity Announcement (FOA) encourages grant applications for Countermeasures Against Chemical Threats (CounterACT) Cooperative Research Projects (U01s). The mission of the CounterACT U01 program is to develop new and improved therapeutics for chemical threats. Chemical threats are toxic chemicals that could be used in a terrorist attack or accidentally released from industrial production, storage or shipping. They include traditional chemical warfare nerve agents such as sarin and VX, and toxic industrial chemicals and pesticides such as cyanide, chlorine, parathion, and sodium fluoroacetate. The scope of the research to be supported includes target and candidate identification and characterization, through candidate optimization and demonstration of in vivo efficacy, through Investigational New Drug (IND) submission and Phase 1 clinical trials when appropriate. Each project must include milestones that create discrete go or no-go decision points in a progressive translational study plan. Mechanism of Support. This FOA will utilize the Research Project Cooperative Agreements (U01) grant mechanism and runs in parallel with an FOA of identical scientific scope, PAR-10-181, that encourages applications for CounterACT Research Centers of Excellence (U54). Funds Available and Anticipated Number of Awards. The participating Institutes intend to commit an average of $6 million per year in Fiscal Years 2011, 2012, and 2013 to fund new and/or competing renewal awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the number, quality, duration, and costs of the applications received.

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