Deep Sequencing and Analysis of Pharmacogenomic Regions: Discovery and Analysis of Genetic Variants Contributing to Drug Abuse and Addiction (R01)

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Purpose. Genome-wide association studies (GWAS) have been critical for identifying genomic regions associated with addiction phenotypes, and have highlighted several areas that require further refinement using deep sequencing approaches. The goal of this FOA is to support studies proposing to use next-generation sequencing technologies to identify the structural variants and SNP variants with rare to moderate frequencies that affect addiction risk in well-characterized samples with drug abuse phenotypes. Applications may propose strategies for deep sequencing based on family based designs; deep sequencing of regions identified by GWAS to be associated with addiction risk; sequencing candidate genes in individuals with extreme phenotypes; or other analytic approaches that capitalize on the genetic architecture. Applicants must use existing DNA samples with appropriately obtained consents for broad data sharing.

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