Defining Genomic Influence on Gene Network Regulation (U01 Clinical Trial Not Allowed)

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The purpose of this FOA is to solicit applications for research projects to explore the effects of genomic variation on phenotypes at the network level. Research projects supported through this FOA will measure changes in the activity of genes and regulatory elements during biological transitions and develop generalizable analytical approaches to understand network-level relationships among genomic variation, functional elements, genes, and phenotypes related to human health and disease. Projects funded through this initiative will become part of the Impact of Genomic Variation on Function Consortium. As members of this Consortium, network projects will be expected to work with one another and other Consortium components to accelerate understanding of how genomic variation impacts human health and disease.

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