Developmental Mechanisms of Human Structural Birth Defects (P01)

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This Funding Opportunity Announcement (FOA) encourages innovative, multidisciplinary, interactive, and synergistic program project (P01) grant applications from institutes/organizations that propose to integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of congenital structural human malformations. To contain costs, each P01 will consist of only three projects, associated cores, and a smaller optional developmental/pilot project. At least one project must propose basic research in an animal model system and at least one project must be clinical or translational in nature. The projects must share a common central theme, focus, or objective on a specific developmental structural malformation or class of anomalies that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans.

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