Developmental Mechanisms of Human Structural Birth Defects (P01)

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-The purpose of this Program Announcement is to support innovative, multidisciplinary, interactive, and synergistic program projects that integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of congenital human malformations. Each Program Project application must consist of at least three component projects. At least one project must be clinical or translational in nature.The component projects must share a common central theme, focus, or objective on a specific developmental defect or malformation that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans. Any non-mammalian or mammalian animal model may be used, as long as it contributes to the common overall theme or objective of the program project. -Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the quality, duration, and costs of the applications received. -This Program Announcement encouragess Program Project (P01) grant applications.

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