Developmental Mechanisms of Human Structural Birth Defects (P01)

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Purpose. This FOA issued by the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) solicits innovative, multidisciplinary, interactive, and synergistic program project (P01) grant applications from institutes/organizations that propose to integrate basic, translational, and clinical approaches to understanding the developmental biology and genetic basis of congenital structural human malformations. To contain costs, each P01 will consist of only three component projects and associated cores. At lease one project must use basic research in an animal model system and at least one project must be clinical or translational in nature. The component projects must share a common central theme, focus, or objective on a specific developmental structural malformation or class of anomalies that is genotypically, mechanistically, biologically, or phenotypically analogous or homologous in both animal models and humans. Mechanism of Support. This FOA will utilize the NIH Program Project (P01) award mechanism. Funds Available and Anticipated Number of Awards. For this funding opportunity, up to $4,000,000 total costs per year over five years for two to three awards are anticipated.

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