Diabetes and Cardiovascular Disease in Older Adults (R21)

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This Funding Opportunity Announcement (FOA) invites applications that propose basic, clinical, and epidemiological outcomes research on the impact of age on the development of, diagnosis, and management of diabetes and cardiovascular disease (CVD) complications in older persons or animal models. Research may focus on, but is not limited to 1) the epidemiology of increasing incidence and prevalence of DM with advancing age, particularly regarding potential racial-ethnic disparities, 2) the elucidation of age-related mechanisms predisposing older adults to diabetes and resultant CVD , 3) understanding the role of aging in increased incidence and severity of CVD outcomes in older diabetics, and 4) determining age-specific prevention, screening, diagnostic, and management strategies of DM in older persons and its CVD complications. Research supported by this initiative is expected to elucidate the role of aging mechanisms that underlie the increased vulnerability of older adults to DM and its CVD complications and to provide evidence-based guidance to improve more appropriate diagnostic criteria, risk stratification, and intervention recommendations to prevent the onset, or improve short- and long-term outcomes, of DM and CVD in older persons.

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