Diet-Induced Changes in Inflammation as Determinants of Colon Cancer (R01)

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-Purpose. This funding opportunity announcement (FOA), issued by the National Cancer Institute (NCI), encourages the submission of grant applications that describe research projects focused on the identification and characterization of diet-induced changes in inflammation linked to colon cancer risks. This FOA is designed to stimulate research efforts that will lead to the identification and characterization of: diet-induced changes in anti- and pro-inflammatory mediators that modulate colon cancer risk; b) genetic polymorphisms that modify the responses to specific bioactive food components with regard to colon cancer inhibition; and c) the physiological effectiveness of dietary components in terms of concentration, activity, duration of exposure, degrees of stability, chemical forms, and receptor-binding affinity in inflammatory colonocytes. This FOA will not support applications that propose epidemiological studies based on diet-related risks of colon cancer. -Mechanism of Support. This FOA uses the NIH research project R01 grant mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-211, that solicits applications under the NIH Exploratory/Developmental (R21) Grant mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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