DoD Breast Cancer Breakthrough Award

archived

The BCRP Breakthrough Award mechanism is being offered for the first time in FY13. The intent of the Breakthrough Award is to support promising research that has the potential to lead to or make breakthroughs in breast cancer. The critical components of this award mechanism are: Impact: Research supported by the Breakthrough Award will have the potential for a major impact and accelerate progress toward ending breast cancer. The impact may be near-term or long-term, but must be significant and move beyond an incremental advancement. Applications must articulate the pathway to making an impact for breast cancer patients, even if clinical impact is not an immediate outcome. Research Scope: Research proposed under this award mechanism may be small- to large-scale projects, at different stages of idea and research development. Four different funding levels, based on the scope of the research, are available for this award mechanism. It is the responsibility of the Principal Investigator (PI) to select the funding level that is most appropriate for the research proposed. The following are general descriptions, although not all-inclusive, of the scope of research projects that would be appropriate to propose under each funding level: • Funding Level 1: Innovative, high-risk/high-reward research that is in the earliest stages of idea development. Research with potential to yield new avenues of investigation. Proof of concept. No preliminary data available. • Funding Level 2: Research that is already supported by preliminary data and has potential to make significant advancements toward translation from the laboratory to the clinic. Demonstration of efficacy in in vivo models, as applicable. • Funding Level 3: Advanced translational studies that have potential for near-term clinical investigation. Small-scale clinical trials may apply. • Funding Level 4: Large-scale projects that will transform and revolutionize the clinical management of breast cancer. Near-term clinical impact is expected. PIs are expected to have experience in successfully leading large-scale projects. Note: An invited oral presentation to the BCRP Integration Panel (IP) is a requirement for application review of Level 4

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