DoD Gulf War Illness, Idea Award

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Impact: Applications must articulate how results will lead to a clinical impact for Veterans with GWI even if a clinical impact is not an immediate outcome. All applications must focus on features of GWI and Veterans of the 1990-1991 Gulf War affected by GWI. It is the responsibility of the PI to clearly and explicitly articulate the project’s potential impact on GWI. FY19 GWIRP Idea Award Topics of Special Interest: The FY19 GWIRP Idea Award has a special interest in the exploration of the topics listed below. Elucidation of mechanisms outside the context of GWI is not within the scope of this funding opportunity. Applicants are not restricted to this list and may propose studies in any other GWI research area relevant to the mission of the GWIRP and in the context of the Overarching Challenges. • Epidemiology of comorbidities and mortality, including gender or ethnic differences, or sinus, respiratory, gastrointestinal, sleep, or dermatological abnormalities as a component of GWI • Interactions among individual symptoms of GWI, including non-refreshing sleep, and how these symptom clusters affect health outcomes and Veterans’ health overall • Genetic factors predisposing individuals to GWI • Molecular signatures (e.g., biomarkers) underlying symptom clusters via genomic, proteomic, metabolic, or epigenetic technologies • Dysregulation of, or abnormal crosstalk between, human body organ systems (e.g., neuroinflammation, autonomic dysfunction). Particular emphasis is placed on the systems listed below. Note: Examination of parameters at both baseline and after challenge (stress, exercise, immune, etc.) and attention to long-term and latent effects of toxicant exposures to closely represent the current status of GWI patients should be considered. ○ Neurological system (central, peripheral, autonomic, and/or neuromuscular) ○ Immune system ○ Endocrine, exocrine, and/or excretory systems, with special attention to kidney and liver (including Cytochrome P450 abnormalities)

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