DoD Peer Reviewed Cancer, Impact Award

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The FY18 PRCRP Impact Award supports hypothesis-driven, high-impact research. The Impact Award mechanism encourages applications that research projects or ideas that specifically focus on critical scientific and clinical cancer issues, which, if successfully addressed, have the potential to make a major impact on at least one of the FY18 PRCRP Topic Areas. Important factors under consideration will be continuity of research, clinical applicability, and leveraging of clinical samples and trials. Through the Impact Award, the PRCRP seeks to build foundations for finding cures in under-funded, under-studied, and/or lethal militarily relevant cancer areas. With the Impact Award, PRCRP offers the unique opportunity to find commonalities in research across multiple cancers that advance the broader cancer field and to address cancer funding disparities within the FY18 PRCRP Topic Areas. The Impact Award supports identifying scientific outcomes through rigorous, robust research that are translatable toward treatment and/or preventive strategies. Research proposed should aim to accelerate promising findings toward clinical applicability and leverage research results to maximize impact. The critical components of this award mechanism are: Impact: The Impact Award is intended to support research that demonstrates the potential to have a major impact on an area of paramount importance in cancer. It is the responsibility of the Principal Investigator (PI) to clearly and explicitly describe the potential impact of the proposed study on at least one of the FY18 PRCRP Topic Areas and to convey its level of significance. Proposed projects may include translational or clinical research, including clinical trials, and must demonstrate clear clinical relevance. The potential impact of the proposed research is expected to be near-term and it must be significant and go beyond an incremental advance . The applicant must articulate the potential impact the proposed work will have on cancer research and/or patient care. Impactful research will, if successful, accelerate the movement of promising ideas into clinical applications. Transformative Research: The Impact Award is intended to support transformative investigations that leapfrog the cancer research field forward by utilizing previous research findings. The proposed study should demonstrate how the research will transform cancer research toward improved patient care in at least one of the FY18 PRCRP Topic Areas and have potential near-term outcomes. The research should make a significant shift toward clinical applicability in at least one of the FY18 PRCRP Topic Areas. Research should challenge paradigms with respect to the endpoint of impact on patient care and outcomes. Research should seek to find commonalities in cancer research to advance the understanding of the cancer field while focusing on at least one of the FY18 PRCRP Topic Areas. Continuity of Research: The Impact Award is intended to support established projects that have moved beyond the realm of basic research and have the potential to result in a near-term impact in clinical research or the clinic. Preliminary Data: Applications must include preliminary data to support feasibility of the study. Any unpublished, preliminary data provided should originate from the laboratory of the PI or a member(s) of the research team. Military Relevance: The proposed research must address at least one of the FY18 PRCRP Military Relevance Focus Areas. The proposed research must be relevant to active duty Service members, Veterans, and their beneficiaries. For more information, review the following websites: PRCRP ( http://cdmrp.army.mil/prcrp/default ); PRCRP Report to Congress ( http://cdmrp.army.mil/prcrp/reports/reports ); Military Health System (MHS) ( http://www.health.mil ); VA ( http://www.va.gov/ ). The proposed research must be relevant to active duty Service members, Veterans, military beneficiaries, and/or the American public. The anticipated direct costs budgeted for the entire period of performance for an FY18 PRCRP Impact Award will not exceed $1,000,000. Refer to Section II.D.5, Funding Restrictions, for detailed funding information.

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