DoD Peer Reviewed Orthopaedic Clinical Trial Award

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The PRORP Clinical Trial Award is intended to support the rapid implementation of clinical trials with the potential to have a significant impact on military combat-related orthopaedic injuries, or non-battle injuries that significantly impact unit readiness and return-to-duty/work rates. The clinical trials may be designed to evaluate promising new products, pharmacologic agents (drugs or biologics), devices, clinical guidance, and/or emerging approaches and technologies. All applications are required to articulate the relevance of the proposed project to military and/or Veteran populations affected by orthopaedic injury. Collaboration with military researchers and clinicians is encouraged, and studies that include active duty military or Veteran participants as all or a portion of the study population will be given higher priority for funding during programmatic review. Applications are being solicited in the following focus areas: Identify and reduce the secondary health effects (e.g., joint contracture, obesity, metabolic syndrome, poor bone health) that follow reduced mobility from traumatic neuromusculoskeletal injury; Strategies to inhibit neuromas at surgical/amputation sites; The application of novel and/or innovative technologies and materials in prosthetic and orthotic device development; Research toward osseointegration of upper extremity prostheses; Research on treatment of non-battle orthopaedic injuries that impact unit readiness and reflect historical return to work rates less than 50% or longer than 6 months; Physical or occupational therapy (PT/OT) interventions to establish optimal rehabilitation and examine the comparative effectiveness of different PT/OT regimes; Clinical trials to restore function after volumetric muscle loss.

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