Effectiveness Research to Prevent Polysubstance-Impaired Driving

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The Centers for Disease Control and Prevention’s (CDC) National Center for Injury Prevention and Control (NCIPC) is soliciting investigator-initiated research to rigorously evaluate and examine effectiveness of interventions, programs, or policies for reducing polysubstance-impaired driving and associated crashes, nonfatal injuries, and/or deaths, while remaining focused on equity (e.g., examining intended and unintended impacts among specific subpopulations). Polysubstance-impaired driving is defined as driving while impaired by two or more substances (e.g., alcohol and opioids). Research may include, but is not limited to, evaluation of the impact of any of the following on reducing polysubstance-impaired driving and related outcomes: (1) social and structural determinant of health interventions, programs, or policies (e.g., neighborhood or built environment-, healthcare access-, or economic-related interventions); (2) interventions, programs, or policies related to preventing harmful substance use and substance use disorders; or (3) evidence-based alcohol-impaired driving interventions (e.g., ignition interlocks, screening and brief intervention) that may also notably reduce polysubstance-impaired driving. Recommended outcomes of interest include crashes associated with driving while impaired by two or more substances and resulting in nonfatal injuries and/or deaths. Because of the difficulty of measuring these recommended outcomes of impaired driving, research proposing an outcome that is not directly measuring polysubstance-impaired driving or its consequences but can be demonstrated to be sufficiently linked to those outcomes (e.g., self-reported polysubstance-impaired driving behavior) will be considered. Data for outcome measurement may include, but are not limited to, crash records, emergency department data, roadside testing data, or self-report survey data. Outcomes should be measured by key measures of equity (e.g., race, ethnicity, income, education).