Enabling Technologies in DNA Repair Research (R21)

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Purpose. This Funding Opportunity Announcement (FOA) is designed to support multidisciplinary teams to develop enabling technologies that will facilitate and stimulate translation of basic research in DNA damage and repair to human population or clinical studies. These projects will develop new tools to measure global DNA repair capacity in individuals or responses in individual DNA repair pathways activated in response to DNA damaging agents. The assays are expected to enable the study of DNA damage response in exposed individuals in clinical and epidemiological studies. Thus, a key goal is the identification and verification of reproducible biomarkers that indicate the levels of specific repair activity or mutagenic outcomes and would provide the basis for assay development. Field or pilot testing of tools or assays is encouraged. Support will be provided for the development of novel assays for detecting DNA damage and repair or for improving existing measures. It is expected that these improved technologies will be appropriate and scalable for epidemiological and clinical studies. Mechanism of Support. This FOA will use the NIH Exploratory/Developmental (R21) grant mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Budget and Project Period: The total project period for an application submitted in response to this funding opportunity may not exceed two years. For an R21, direct costs are limited to $275,000 over a two-year period, with no more than $200,000 in direct costs allowed in any single year.

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