Erythroid Lineage Molecular Toolbox (R01)

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-Purpose. The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) announces a funding opportunity designed to stimulate research in erythroid cells. The aim of this Funding Opportunity Announcement (FOA) is to contribute to a complete description of expressed erythroid molecular biological components and to create reagents useful for study of the erythroid cell lineages. Components include genes that are expressed in erythroid cells, either during development or during differentiation, and the proteins that are translated in erythroid cells, potentially with post-translational modifications or subcellular localizations that are unique to erythroid cells. A long range goal of this program is to unify genetics and the study of function by facilitating characterization of the structure-function relationships between the expressed genes in the erythroid lineages and cell morphology, physiology, and disease phenotypes. Development of new technologies to facilitate applications of this genomic information is also encouraged. Applicants are encouraged to refer to the NIDDK's Progenitor Cell Genome Anatomy Projects at http://www.scgap.org to find current resources that are available. Synergy with existing Progenitor Cell Genome Anatomy Projects is encouraged. -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism and will run in parallel with a FOA of identical scientific scope (PA-06-170) that will utilize the Exploratory/Developmental Research (R21) grant mechanism. -Funds Available and Anticipated Number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received.

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