Erythropoiesis: Components and Mechanisms (R01)

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This Funding Opportunity Announcement (FOA) issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and the National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health, encourages investigator-initiated R01 applications that propose hypothesis-driven research using erythroid cells. The aim of this program is to support research efforts towards a complete description of the molecular and cellular components of erythropoiesis and how these components contribute to erythropoiesis. Components include genes that are expressed (transcriptome) in erythroid cells, either during development or during differentiation, and the proteins (proteome) that are translated in erythroid cells, especially with post-translational modifications or subcellular localizations that are unique to erythroid cells. A long range goal of this program is to generate a concise description of erythropoiesis that unifies genetics, molecular processes and cytokine determinants in the erythroid lineages so that new therapeutics may be developed to measure and combat anemia.

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