Etiology and Pathophysiology of Sleep Disordered Breathing in Pregnancy (R01)

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This FOA issued by the National Heart, Lung, and Blood Institute (NHLBI), the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), and the National Institute of Nursing Research (NINR), encourages research project grant applications (R01) investigating: (1) mechanisms underlying the etiology of incident sleep disordered breathing (SDB) in pregnancy; (2) mechanisms coupling SDB to maternal heart, lung, and blood pathophysiology; (3) mechanisms through which SDB affects placental development and function and associated adverse pregnancy outcomes; and (4) mechanisms linking SDB to conditions in the intrauterine environment that result in altered fetal development and predispose offspring to obesity, metabolic, and cardiovascular disease. The goal of this program is to identify clinically relevant mechanisms of SDB etiology and pathophysiology that will open new avenues to develop therapeutic strategies to reduce the maternal and fetal risks of SDB exposure during pregnancy. Multi-disciplinary research teams are strongly encouraged.

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