Etiology, Prevention, and Treatment of Hepatocellular Carcinoma (R01)

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-Purpose. With this Funding Opportunity Announcement (FOA), the National Cancer Institute (NCI), the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), and the National Institute on Alcohol Abuse and Alcoholism (NIAAA) encourage grant applications that: (a) address the etiology and etiologic mechanisms of hepatocellular carcinoma (HCC); (b) propose development of animal models for HCC; (c) propose novel approaches to prevent HCC malignancy; (d) propose therapeutic or diagnostic tools for reliable prognostic indicators for HCC; and/or (e) develop therapeutic approaches to minimize morbidity and mortality associated with HCC in humans. The primary focus of the proposed project must be on the basic biology, prevention, and/or treatment of liver cancer. Applications solely concerned with population studies and epidemiology will not be supported in connection with this FOA. -Mechanism of Support. This FOA will utilize the R01 grant mechanism and runs in parallel with two FOAs of similar scientific scope: (1) PA-08-244, for pilot exploratory/developmental projects using the R21 mechanism; and (2) PAR-08-245, for program project grants under the P01 mechanism. -Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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