Exceptionally Innovative Tools and Technologies for Single Cell Analysis (R21)

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This Funding Opportunity Announcement (FOA) issued by the National Institutes of Health, solicits early stage, high-risk/high-impact applications to develop next-generation tools that distinguish heterogeneous states among cells in situ. Applications should define the current state of technology as a benchmark against which the new tool(s) will be measured and should propose proof-of-concept testing of the tool(s) in a complex biological tissue or living organism. The new tools should provide substantially increased sensitivity, selectivity, spatiotemporal resolution, scalability of multiple global or functional measures of single cells. A particular emphasis for this FOA is on measures that minimize cell perturbation and permit viability of cells for repeated measures over time. These novel technologies will aid in obtaining a fine-grained, integrative and dynamic view of heterogeneous cellular states/classes and will provide innovative platforms to transform research into the cellular basis of diseases.

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