Exfoliated Cells, Bioactive Food Components, and Cancer (R01)

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Purpose. The National Cancer Institute (NCI) invites applications for new R01 grants focusing on research to critically evaluate the use of exfoliated cells to monitor the physiological effects of dietary bioactive food components thought to be involved with cancer prevention. The objective is to encourage interdisciplinary collaborations between scientists engaged in research using exfoliated cells and those conducting nutrition research related to cancer prevention. This research will help determine the utility of exfoliated cells as a model system to monitor both the absorption and retention of bioactive food components and the concomitant alterations in genomic and epigenetic events that occur in intact cells. Mechanism of Support. This funding opportunity announcement (FOA) will utilize the NIH Research Project Grant (R01) award mechanism and runs in parallel with an FOA of identical scientific scope PA-08-031, which solicits applications under the NIH Exploratory/Developmental Grant (R21) mechanism. Funds Available and Anticipated Number of Awards. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications. Eligible Institutions/Organizations. Public/State Controlled Institutions of Higher Education; Private Institutions of Higher Education; Non-Profits With 501(c)(3) IRS Status (Other Than Institutions of Higher Education); Non-Profits Without 501(c)(3) IRS Status (Other Than Institutions of Higher Education); Small Businesses; For-Profit Organizations (Other Than Small Businesses); State Governments; U.S. Territories or Possessions; Indian/Native American Tribal Governments (Federally Recognized); Indian/Native American Tribal Governments (Other Than Federally Recognized); Indian/Native American Tribally Designated Organizations; Non-Domestic (non-U.S.) Entities (Foreign Organization); Hispanic-Serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); Alaska Native and Native Hawaiian-Serving Institutions; and Regional Organizations; Eligible agencies of the Federal government; and Faith-based or community-based organizations. Eligible Project Directors/Principal Investigators (PDs/PIs). Individuals with the skills, knowledge, and resources necessary to carry out the proposed research are invited to work with their institution/organization to develop an application for support. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Number of Applications. Applicants may submit more than one application, provided each application is scientifically distinct. Renewals and Resubmissions. Applications can be renewed by competing for additional project periods. Applicants may submit a resubmission application, but such application must include an Introduction addressing the previous peer review critique (Summary Statement). Number of PDs/PIs. More than one PD/PI, or multiple PDs/PIs, may be designated on the application.

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