Exfoliated Cells, Bioactive Food Components, and Cancer (R21)

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Purpose. The National Cancer Institute (NCI) invites applications for new R21 grants that focus on research to critically evaluate the use of exfoliated cells to monitor the physiological effects of dietary bioactive food components thought to be involved with cancer prevention. The objective is to encourage interdisciplinary collaborations between scientists engaged in research using exfoliated cells and those conducting nutrition research related to cancer prevention. This research will help determine the utility of exfoliated cells as a model system to monitor both the absorption and retention of bioactive food components and the concomitant alterations in genomic and epigenetic events that occur in intact cells. Mechanism of Support. This FOA utilizes the NIH Exploratory/Developmental Grant (R21) mechanism and runs in parallel with an FOA of identical scientific scope, PA-08-030, that solicits applications under the NIH Research Project Grant (R01) mechanism. The R21 grant is not renewable. Funds Available and Anticipated number of Awards. Because the nature and scope of the proposed research will vary from application to application, it is anticipated that the size and duration of each award will also vary. The total amount awarded and the number of awards will depend upon the mechanism numbers, quality, duration, and costs of the applications received. Budget and Project Period: The total project period for an application submitted in response to this funding opportunity may not exceed 2 years. Direct costs are limited to $275,000 over an R21 2-year period, with no more than $200,000 in direct costs allowed in any single year. Eligible organizations: Public/State Controlled Institution of Higher Education; Private Institution of Higher Education; Nonprofit with 501(c)(3) IRS Status (Other than Institution of Higher Education); Nonprofit without 501(c)(3) IRS Status (Other than Institution of Higher Education); Small Business; For-Profit Organizations (Other than Small Business); State Governments; U.S. Territory or Possession; Non-Domestic (non-U.S.) Entity (Foreign Organization); Regional Organization; Eligible agencies of the Federal government Eligible Project Directors/Principal Investigators (PDs/PIs): Any individuals from the applicant institutions who have the skills, knowledge, and resources necessary to carry out the proposed research. Individuals from underrepresented racial and ethnic groups as well as individuals with disabilities are always encouraged to apply for NIH support. Renewals. R21 awards are not renewable. Resubmissions. Up to two resubmissions (formerly revisions/amendments") of a previously reviewed R21 grant application may be submitted. Application and Submission Information: Applicants may submit more than one application, provided each application is scientifically distinct.

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