Functional Glycomics in HIV Vaccine Design (R01)

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Glycans play key roles in the transmission, antigenicity, and immunogenicity of the HIV-1 envelope protein. Glycans also modulate the immune response, playing an essential role in both innate and adaptive immunity. The purpose of this Funding Opportunity Announcement (FOA) is to stimulate and foster multi-disciplinary investigator- initiated collaborative research to 1) investigate structural and conformational features of glycosylation that may lead to novel HIV vaccine design approaches, and 2) to elucidate the impact of differential glycosylation on the quality of the immune response to HIV. Ultimately, the discovery of a safe, effective, prophylactic vaccine that provides long-term protection from HIV infection may depend on novel approaches that incorporate new knowledge of the key role glycans play in the elicitation and maturation of broadly neutralizing antibodies and effector immune responses.

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