Functioning of People with Mental Disorders (R01)

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-Purpose. Although considerable advances have been made in improving the symptoms associated with mental disorders, symptom improvement is often only modestly associated with improvements in daily functioning (i.e., the performance of social, occupational, and instrumental tasks of daily living), and most current treatments have limited impact on the functioning and participation of those with mental disorders. The purpose of this Funding Opportunity Announcement (FOA), issued by the National Institute of Mental Health (NIMH), is the application of biobehavioral science methods and approaches to: a) develop and refine definitions and measures of function, disability, and daily participation relevant to those with mental disorders; b) understand the ecological mechanisms, independent of symptom severity, that contribute to functioning and disability in this population; and c) develop and test novel interventions that specifically and directly target functional capacity and performance deficits of this population. Emphasis will be on the application of basic behavioral processes (e.g., cognition, affect, knowledge, attitudes, motivation, learning, decision-making, interpersonal processes), and environmental parameters (e.g., social support, structural adaptations, community involvement) that influence functional outcome.-Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. Applications of identical scientific scope and appropriateness for the grant mechanism are encouraged also under the NIH Small Research Grant (R03), the NIMH Clinical Exploratory/Developmental Research Grant (R34), and the NIMH Collaborative Grants Program (Collaborative R01) award mechanisms, responding to FOAs PA-06-180, PA-06-248, and PA-07-092, respectively.

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