FY16 Tuberous Sclerosis Complex Synergistic Idea Development Award

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The TSCRP Synergistic Idea Development Award mechanism is being offered for the first time in FY16. The Synergistic Idea Development Award supports new or existing partnerships between two or three Principal Investigators (PIs) who should utilize their complementary and synergistic perspectives to significantly accelerate advances in TSC research to support the TSCRP vision to lessen the impact of TSC. Although groundbreaking research often involves a degree of risk, applications should be based on a sound scientific rationale that is established through logical reasoning, critical review and analysis of the literature, and preliminary data relevant to TSC and the proposed project. Research deemed innovative may represent a new paradigm, challenge current paradigms, explore existing problems from new perspectives, or exhibit other highly creative qualities. Research that is an incremental advance upon published data is not considered innovative. The Synergistic Idea Development Award mechanism requires multiple investigators in a wide spectrum of disciplines including, but not limited to, basic science, engineering, bioinformatics, population science, translational research, and clinical research to jointly design a single project. One PI will be identified as the Initiating PI and will be responsible for the majority of the administrative tasks associated with application submission. The other PI(s) will be identified as a Partnering PI(s). Initiating and Partnering PIs each have different submission requirements, as described in Section II; however, all PIs should contribute significantly to the development and execution of the proposed research project. If recommended for funding, each PI will receive his/her own award. The research project must be supported by the unique expertise, experience, and abilities of each PI, and it must clearly define the synergistic components (i.e., leveraging disciplines, expertise, or critical resources) that will significantly advance the project such that the research outcomes as a whole will be realized rapidly and efficiently and could not otherwise be accomplished through independent efforts of a single PI. Multidisciplinary projects are encouraged, and multi-institutional projects are allowed. Each proposed study must include clearly stated plans for interactions among all PIs and organizations involved. The plans must include communication, coordination of research progress and results, and data transfer. Additionally, multi-institutional applications must provide an intellectual property plan to resolve potential intellectual and material property issues and to remove institutional barriers that might interfere with achieving high levels of cooperation to ensure the successful completion of this award.

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