Genome-Wide Association Analysis of Existing Data Sets for Arthritis and Musculoskeletal and Skin Diseases (R01)

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-Purpose. This Funding Opportunity Announcement (FOA) issued by the National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, solicits applications proposing genome-wide association studies (GWAS) of phenotypes relevant to the NIAMS mission, to be conducted with existing genetic and phenotypic data, such as may be obtained from the NIH database of Genotype and Phenotype (dbGaP) or other sources of genotype and phenotype data.  -Mechanism of Support. This FOA will utilize the NIH Research Project Grant (R01) award mechanism. . In some instances, an active NIAMS R01 award may currently support the recruitment and/or phenotypic characterization of subjects appropriate for GWAS, and genotypes for these subjects may be available as a result of previous work. In such instances, investigators may submit a revision (formerly competing supplement) application in response to this FOA, to support genome-wide association analysis, provided the application conforms to both the budgetary requirements of this FOA and the format requirements of revision applications. -Funds Available and Anticipated Number of Awards. The NIAMS expects to commit approximately $1 million in each of fiscal years 2009, 2010, and 2011, to support two to four new projects each year. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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