Gut-Liver-Brain Interactions in Alcohol-Induced Pathogenesis (R21)

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Purpose. The goal of this Funding Opportunity Announcement (FOA), issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), is to stimulate innovative research that will determine (1) how alcohol disrupts gut-liver-brain physiological communications, and (2) how these alterations contribute to the development and exacerbation of alcohol-associated diseases. These investigations are expected to provide a more comprehensive understanding of cellular and molecular mechanisms by which alcohol impairs homeostatic functions at both organ and systemic levels and initiates/promotes tissue injury. Mechanism of Support. This FOA will utilize the NIH Exploratory/Developmental Research Grant (R21) mechanism and runs in parallel with a FOA of identical scientific scope, RFA-AA-10-007, that solicits applications under the Research Project Grant R01 mechanism. Funds Available and Anticipated Number of Awards. The NIAAA intends to commit a total of approximately $2,000,000 to this FOA and the companion RFA-AA-10-007 in FY10 to award up to 8 applications. Awards issued under this FOA are contingent upon the availability of funds and the submission of a sufficient number of meritorious applications.

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